Drug interactions
Donepezil + Umeclidinium-vilanterol
Severity: Moderate
Donepezil and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Donepezil can prolong the QT interval and cause bradycardia, and vilanterol, a beta-2 agonist, may also affect QT and heart rate at higher exposures. Additionally, donepezil's cholinergic action opposes the antimuscarinic effect of umeclidinium, which could reduce its bronchodilator benefit. Clinically significant effects are uncommon at usual doses.
What this interaction means in plain words
Donepezil and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Donepezil belongs to Central Nervous System; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Additive effects on cardiac repolarization plus pharmacodynamic opposition between cholinesterase inhibition and muscarinic blockade.
What to do
Monitor heart rate and ECG in patients with existing QT risk factors, bradycardia or conduction disease. Watch for reduced respiratory symptom control and review whether both agents are needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Frequently asked questions
Can I take Donepezil with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Donepezil and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Donepezil can prolong the QT interval and cause bradycardia, and vilanterol, a beta-2 agonist, may also affect QT and heart rate at higher exposures. Additionally, donepezil's cholinergic action opposes the antimuscarinic effect of umeclidinium, which could reduce its bronchodilator benefit. Clinically significant effects are uncommon at usual doses.
How serious is the interaction between Donepezil and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG in patients with existing QT risk factors, bradycardia or conduction disease. Watch for reduced respiratory symptom control and review whether both agents are needed.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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