Drug interactions
Dong quai + Sulindac
Severity: Moderate
Dong quai and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dong quai contains coumarin derivatives and has been associated with increased INR in patients on warfarin. With sulindac, bleeding risk may be additive, although direct evidence is limited.
What this interaction means in plain words
Dong quai and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive effects on hemostasis from coumarin constituents and possible antiplatelet activity of dong quai plus NSAID platelet inhibition.
What to do
Advise avoiding dong quai while taking sulindac. If both are used, monitor for bruising, bleeding and melena.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Dong quai with Sulindac?
MediHelp rates the interaction as moderate. Dong quai and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dong quai contains coumarin derivatives and has been associated with increased INR in patients on warfarin. With sulindac, bleeding risk may be additive, although direct evidence is limited.
How serious is the interaction between Dong quai and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise avoiding dong quai while taking sulindac. If both are used, monitor for bruising, bleeding and melena.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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