Drug interactions
Dopexamine + Irbesartan
Severity: Moderate
Dopexamine and Irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dopexamine is a short-acting vasodilator used in intensive care and can add to the hypotensive effect of irbesartan. Its beta-2 activity may also lower serum potassium, partly opposing the ARB.
What this interaction means in plain words
Dopexamine and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation; beta-2 mediated cellular potassium uptake opposes ARB-related potassium retention.
What to do
Monitor blood pressure and serum potassium during dopexamine infusion. Consider withholding irbesartan in hemodynamically unstable patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Frequently asked questions
Can I take Dopexamine with Irbesartan?
MediHelp rates the interaction as moderate. Dopexamine and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dopexamine is a short-acting vasodilator used in intensive care and can add to the hypotensive effect of irbesartan. Its beta-2 activity may also lower serum potassium, partly opposing the ARB.
How serious is the interaction between Dopexamine and Irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and serum potassium during dopexamine infusion. Consider withholding irbesartan in hemodynamically unstable patients.
What other medicines interact with Irbesartan?
MediHelp also lists interactions of Irbesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Irbesartan page.
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