Drug interactions
Dopexamine + Nadolol
Severity: Moderate
Dopexamine and Nadolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dopexamine is a beta-2 agonist and dopamine receptor agonist, and nonselective beta blockade with nadolol opposes its hemodynamic effects. Reduced benefit of dopexamine and unpredictable blood pressure changes may occur.
What this interaction means in plain words
Dopexamine and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism at beta-adrenergic receptors.
What to do
Monitor hemodynamics closely during dopexamine infusion in patients on nadolol. Titrate dopexamine to effect or consider an alternative agent.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nadolol
Frequently asked questions
Can I take Dopexamine with Nadolol?
MediHelp rates the interaction as moderate. Dopexamine and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dopexamine is a beta-2 agonist and dopamine receptor agonist, and nonselective beta blockade with nadolol opposes its hemodynamic effects. Reduced benefit of dopexamine and unpredictable blood pressure changes may occur.
How serious is the interaction between Dopexamine and Nadolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemodynamics closely during dopexamine infusion in patients on nadolol. Titrate dopexamine to effect or consider an alternative agent.
What other medicines interact with Nadolol?
MediHelp also lists interactions of Nadolol with, for example, Acebutolol, Adrenaline-articaine, Amifostine. The full list is on the Nadolol page.
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