Drug interactions
Dopexamine + Tranylcypromine
Severity: Contraindicated
Dopexamine and Tranylcypromine: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tranylcypromine blocks breakdown of catecholamines, so the sympathomimetic effects of dopexamine may be greatly exaggerated. This can cause marked hypertension, tachycardia and arrhythmias.
What this interaction means in plain words
Dopexamine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Irreversible MAO inhibition increases catecholamine availability and potentiates adrenergic and dopaminergic stimulation, producing additive pressor effects.
What to do
Avoid the combination; choose a non-adrenergic inotropic strategy where possible. If a sympathomimetic is unavoidable, use only under intensive hemodynamic monitoring with very cautious dosing.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dopexamine and Tranylcypromine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Dopexamine with Tranylcypromine?
MediHelp rates the interaction as contraindicated. Dopexamine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tranylcypromine blocks breakdown of catecholamines, so the sympathomimetic effects of dopexamine may be greatly exaggerated. This can cause marked hypertension, tachycardia and arrhythmias.
How serious is the interaction between Dopexamine and Tranylcypromine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; choose a non-adrenergic inotropic strategy where possible. If a sympathomimetic is unavoidable, use only under intensive hemodynamic monitoring with very cautious dosing.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
