Drug interactions
Dosulepin + Doxylamine
Severity: Moderate
Dosulepin and Doxylamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dosulepin is a sedating tricyclic antidepressant with strong anticholinergic effects, and doxylamine adds further sedation and anticholinergic load. This can cause marked drowsiness, confusion, dry mouth, constipation and urinary retention.
What this interaction means in plain words
Dosulepin and Doxylamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dosulepin belongs to Central Nervous System; Doxylamine belongs to Respiratory.
Why it happens
Additive CNS depression and antimuscarinic effects.
What to do
Avoid combining where possible, especially in older adults. Monitor for oversedation and anticholinergic toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxylamine
Other interactions of Dosulepin
- Dosulepin + Isocarboxazid Contraindicated
- Dosulepin + Phenelzine Contraindicated
- Dosulepin + Thioridazine Contraindicated
- Dosulepin + Tranylcypromine Contraindicated
- Amitriptyline + Dosulepin Major
- Buprenorphine + Dosulepin Major
Frequently asked questions
Can I take Dosulepin with Doxylamine?
MediHelp rates the interaction as moderate. Dosulepin and Doxylamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dosulepin is a sedating tricyclic antidepressant with strong anticholinergic effects, and doxylamine adds further sedation and anticholinergic load. This can cause marked drowsiness, confusion, dry mouth, constipation and urinary retention.
How serious is the interaction between Dosulepin and Doxylamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, especially in older adults. Monitor for oversedation and anticholinergic toxicity.
What other medicines interact with Doxylamine?
MediHelp also lists interactions of Doxylamine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Doxylamine page.
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