Drug interactions
Dosulepin + Fesoterodine
Severity: Moderate
Dosulepin and Fesoterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dosulepin is a tricyclic antidepressant with significant anticholinergic effects that add to those of fesoterodine. This can cause dry mouth, constipation, urinary retention, blurred vision and confusion.
What this interaction means in plain words
Dosulepin and Fesoterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dosulepin belongs to Central Nervous System; Fesoterodine belongs to Genitourinary.
Why it happens
Additive anticholinergic effects at muscarinic receptors.
What to do
Monitor for anticholinergic adverse effects, especially in older patients, and consider a less anticholinergic antidepressant if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fesoterodine
Other interactions of Dosulepin
- Dosulepin + Isocarboxazid Contraindicated
- Dosulepin + Phenelzine Contraindicated
- Dosulepin + Thioridazine Contraindicated
- Dosulepin + Tranylcypromine Contraindicated
- Amitriptyline + Dosulepin Major
- Buprenorphine + Dosulepin Major
Frequently asked questions
Can I take Dosulepin with Fesoterodine?
MediHelp rates the interaction as moderate. Dosulepin and Fesoterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dosulepin is a tricyclic antidepressant with significant anticholinergic effects that add to those of fesoterodine. This can cause dry mouth, constipation, urinary retention, blurred vision and confusion.
How serious is the interaction between Dosulepin and Fesoterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects, especially in older patients, and consider a less anticholinergic antidepressant if symptoms develop.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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