Drug interactions
Dosulepin + Galantamine
Severity: Moderate
Dosulepin and Galantamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dosulepin is a tricyclic antidepressant with marked anticholinergic activity that opposes galantamine. This may blunt cognitive benefit and add to confusion, and tricyclics also carry cardiac conduction effects alongside possible bradycardia from galantamine.
What this interaction means in plain words
Dosulepin and Galantamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dosulepin belongs to Central Nervous System; Galantamine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism between a cholinesterase inhibitor and an anticholinergic tricyclic antidepressant.
What to do
Prefer an antidepressant with low anticholinergic activity, such as an SSRI. If dosulepin is continued, monitor cognition, heart rate and ECG.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Galantamine
- Galantamine + Memantine-donepezil Major
- Galantamine + Physostigmine Major
- Galantamine + Ponesimod Major
- Galantamine + Rivastigmine Major
- Amifampridine + Galantamine Moderate
- Amiodarone + Galantamine Moderate
Other interactions of Dosulepin
- Dosulepin + Isocarboxazid Contraindicated
- Dosulepin + Phenelzine Contraindicated
- Dosulepin + Thioridazine Contraindicated
- Dosulepin + Tranylcypromine Contraindicated
- Amitriptyline + Dosulepin Major
- Buprenorphine + Dosulepin Major
Frequently asked questions
Can I take Dosulepin with Galantamine?
MediHelp rates the interaction as moderate. Dosulepin and Galantamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dosulepin is a tricyclic antidepressant with marked anticholinergic activity that opposes galantamine. This may blunt cognitive benefit and add to confusion, and tricyclics also carry cardiac conduction effects alongside possible bradycardia from galantamine.
How serious is the interaction between Dosulepin and Galantamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an antidepressant with low anticholinergic activity, such as an SSRI. If dosulepin is continued, monitor cognition, heart rate and ECG.
What other medicines interact with Galantamine?
MediHelp also lists interactions of Galantamine with, for example, Memantine-donepezil, Physostigmine, Ponesimod. The full list is on the Galantamine page.
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