Drug interactions
Dosulepin + Lorazepam
Severity: Moderate
Dosulepin and Lorazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dosulepin is a sedating tricyclic antidepressant, and with lorazepam it increases drowsiness and psychomotor impairment. At high doses or in overdose the combination may deepen CNS and respiratory depression.
What this interaction means in plain words
Dosulepin and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dosulepin belongs to Central Nervous System; Lorazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression from benzodiazepine GABA-A enhancement and the antihistaminic and anticholinergic sedative effects of the tricyclic.
What to do
Start at low doses and monitor for excessive sedation, especially at treatment initiation and in the elderly. Counsel against driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorazepam
Other interactions of Dosulepin
- Dosulepin + Isocarboxazid Contraindicated
- Dosulepin + Phenelzine Contraindicated
- Dosulepin + Thioridazine Contraindicated
- Dosulepin + Tranylcypromine Contraindicated
- Amitriptyline + Dosulepin Major
- Buprenorphine + Dosulepin Major
Frequently asked questions
Can I take Dosulepin with Lorazepam?
MediHelp rates the interaction as moderate. Dosulepin and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dosulepin is a sedating tricyclic antidepressant, and with lorazepam it increases drowsiness and psychomotor impairment. At high doses or in overdose the combination may deepen CNS and respiratory depression.
How serious is the interaction between Dosulepin and Lorazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start at low doses and monitor for excessive sedation, especially at treatment initiation and in the elderly. Counsel against driving until the response is known.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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