Drug interactions
Dosulepin + Neostigmine
Severity: Moderate
Dosulepin and Neostigmine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dosulepin, a tricyclic antidepressant, has strong anticholinergic effects that oppose neostigmine. Neostigmine may be less effective, and dosulepin can also cause confusing anticholinergic symptoms.
What this interaction means in plain words
Dosulepin and Neostigmine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dosulepin belongs to Central Nervous System; Neostigmine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism between tricyclic muscarinic blockade and cholinesterase inhibition.
What to do
Monitor neostigmine effect, such as muscle strength in myasthenia gravis, and consider an antidepressant with less anticholinergic activity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Neostigmine
Other interactions of Dosulepin
- Dosulepin + Isocarboxazid Contraindicated
- Dosulepin + Phenelzine Contraindicated
- Dosulepin + Thioridazine Contraindicated
- Dosulepin + Tranylcypromine Contraindicated
- Amitriptyline + Dosulepin Major
- Buprenorphine + Dosulepin Major
Frequently asked questions
Can I take Dosulepin with Neostigmine?
MediHelp rates the interaction as moderate. Dosulepin and Neostigmine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dosulepin, a tricyclic antidepressant, has strong anticholinergic effects that oppose neostigmine. Neostigmine may be less effective, and dosulepin can also cause confusing anticholinergic symptoms.
How serious is the interaction between Dosulepin and Neostigmine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neostigmine effect, such as muscle strength in myasthenia gravis, and consider an antidepressant with less anticholinergic activity.
What other medicines interact with Neostigmine?
MediHelp also lists interactions of Neostigmine with, for example, Huperzine a, Physostigmine, Pyridostigmine. The full list is on the Neostigmine page.
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