Drug interactions
Dosulepin + Scopolamine
Severity: Moderate
Dosulepin and Scopolamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dosulepin is a tricyclic antidepressant with notable anticholinergic and sedative properties. With scopolamine, antimuscarinic effects are additive and may cause dry mouth, constipation, urinary retention, blurred vision, confusion and drowsiness.
What this interaction means in plain words
Dosulepin and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dosulepin belongs to Central Nervous System; Scopolamine belongs to Respiratory.
Why it happens
Additive muscarinic receptor antagonism and sedation.
What to do
Monitor for anticholinergic toxicity and sedation, especially in older patients, and lower doses or switch if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Scopolamine
Other interactions of Dosulepin
- Dosulepin + Isocarboxazid Contraindicated
- Dosulepin + Phenelzine Contraindicated
- Dosulepin + Thioridazine Contraindicated
- Dosulepin + Tranylcypromine Contraindicated
- Amitriptyline + Dosulepin Major
- Buprenorphine + Dosulepin Major
Frequently asked questions
Can I take Dosulepin with Scopolamine?
MediHelp rates the interaction as moderate. Dosulepin and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dosulepin is a tricyclic antidepressant with notable anticholinergic and sedative properties. With scopolamine, antimuscarinic effects are additive and may cause dry mouth, constipation, urinary retention, blurred vision, confusion and drowsiness.
How serious is the interaction between Dosulepin and Scopolamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and sedation, especially in older patients, and lower doses or switch if symptoms occur.
What other medicines interact with Scopolamine?
MediHelp also lists interactions of Scopolamine with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Scopolamine page.
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