Drug interactions
Dosulepin + Tolterodine
Severity: Moderate
Dosulepin and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dosulepin is a tricyclic antidepressant with significant anticholinergic activity, so adding tolterodine increases total antimuscarinic load. This can cause dry mouth, constipation, urinary retention, tachycardia, blurred vision and confusion. Tricyclics also affect cardiac conduction, which adds some concern.
What this interaction means in plain words
Dosulepin and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dosulepin belongs to Central Nervous System; Tolterodine belongs to Genitourinary.
Why it happens
Additive antimuscarinic effects of both drugs.
What to do
Monitor for anticholinergic toxicity, especially in older patients, and consider an alternative antidepressant with lower anticholinergic activity. Reduce doses or stop one drug if urinary retention or cognitive effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolterodine
Other interactions of Dosulepin
- Dosulepin + Isocarboxazid Contraindicated
- Dosulepin + Phenelzine Contraindicated
- Dosulepin + Thioridazine Contraindicated
- Dosulepin + Tranylcypromine Contraindicated
- Amitriptyline + Dosulepin Major
- Buprenorphine + Dosulepin Major
Frequently asked questions
Can I take Dosulepin with Tolterodine?
MediHelp rates the interaction as moderate. Dosulepin and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dosulepin is a tricyclic antidepressant with significant anticholinergic activity, so adding tolterodine increases total antimuscarinic load. This can cause dry mouth, constipation, urinary retention, tachycardia, blurred vision and confusion. Tricyclics also affect cardiac conduction, which adds some concern.
How serious is the interaction between Dosulepin and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity, especially in older patients, and consider an alternative antidepressant with lower anticholinergic activity. Reduce doses or stop one drug if urinary retention or cognitive effects appear.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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