Drug interactions
Doxazosin + Duvelisib
Severity: Moderate
Doxazosin and Duvelisib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib is a CYP3A4 inhibitor and can raise exposure to CYP3A4 substrates such as doxazosin. This may increase hypotension, dizziness and syncope.
What this interaction means in plain words
Doxazosin and Duvelisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxazosin belongs to Genitourinary; Duvelisib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated metabolism of doxazosin by duvelisib increases doxazosin exposure.
What to do
Monitor blood pressure and orthostatic symptoms, and consider a lower doxazosin dose while duvelisib is given.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxazosin
- Alfuzosin + Doxazosin Major
- Amifostine + Doxazosin Major
- Avanafil + Doxazosin Major
- Doxazosin + Dutasteride-tamsulosin Major
- Doxazosin + Phentolamine Major
- Doxazosin + Prazosin Major
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Doxazosin with Duvelisib?
MediHelp rates the interaction as moderate. Doxazosin and Duvelisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duvelisib is a CYP3A4 inhibitor and can raise exposure to CYP3A4 substrates such as doxazosin. This may increase hypotension, dizziness and syncope.
How serious is the interaction between Doxazosin and Duvelisib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, and consider a lower doxazosin dose while duvelisib is given.
What other medicines interact with Doxazosin?
MediHelp also lists interactions of Doxazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Doxazosin page.
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