Drug interactions
Doxazosin + Enalapril-hydrochlorothiazide
Severity: Moderate
Doxazosin and Enalapril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxazosin adds to the blood pressure lowering of enalapril and hydrochlorothiazide and can cause pronounced first-dose orthostatic hypotension, dizziness and syncope.
What this interaction means in plain words
Doxazosin and Enalapril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxazosin belongs to Genitourinary; Enalapril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive vasodilatory and antihypertensive effects of alpha-1 blockade with ACE inhibition and diuresis.
What to do
Start doxazosin at the lowest dose at bedtime and titrate slowly, monitoring standing blood pressure. Counsel patients about rising slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Doxazosin and Enalapril-hydrochlorothiazide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Doxazosin
- Alfuzosin + Doxazosin Major
- Amifostine + Doxazosin Major
- Avanafil + Doxazosin Major
- Doxazosin + Dutasteride-tamsulosin Major
- Doxazosin + Phentolamine Major
- Doxazosin + Prazosin Major
Frequently asked questions
Can I take Doxazosin with Enalapril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Doxazosin and Enalapril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxazosin adds to the blood pressure lowering of enalapril and hydrochlorothiazide and can cause pronounced first-dose orthostatic hypotension, dizziness and syncope.
How serious is the interaction between Doxazosin and Enalapril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start doxazosin at the lowest dose at bedtime and titrate slowly, monitoring standing blood pressure. Counsel patients about rising slowly.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
