Drug interactions
Doxazosin + Etodolac
Severity: Moderate
Doxazosin and Etodolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etodolac may reduce the blood pressure lowering effect of doxazosin by promoting fluid retention. The effect is most relevant with regular long-term NSAID use.
What this interaction means in plain words
Doxazosin and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxazosin belongs to Genitourinary; Etodolac belongs to Musculoskeletal.
Why it happens
Inhibition of prostaglandin synthesis causes sodium and water retention.
What to do
Monitor blood pressure when starting or stopping etodolac and adjust doxazosin dosing if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxazosin
- Alfuzosin + Doxazosin Major
- Amifostine + Doxazosin Major
- Avanafil + Doxazosin Major
- Doxazosin + Dutasteride-tamsulosin Major
- Doxazosin + Phentolamine Major
- Doxazosin + Prazosin Major
Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Frequently asked questions
Can I take Doxazosin with Etodolac?
MediHelp rates the interaction as moderate. Doxazosin and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etodolac may reduce the blood pressure lowering effect of doxazosin by promoting fluid retention. The effect is most relevant with regular long-term NSAID use.
How serious is the interaction between Doxazosin and Etodolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when starting or stopping etodolac and adjust doxazosin dosing if needed.
What other medicines interact with Doxazosin?
MediHelp also lists interactions of Doxazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Doxazosin page.
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