Drug interactions
Doxazosin + Felodipine
Severity: Moderate
Doxazosin and Felodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combination can produce additive hypotension, dizziness and peripheral edema, especially at initiation or dose increases. It is a recognized regimen, but needs monitoring.
What this interaction means in plain words
Doxazosin and Felodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxazosin belongs to Genitourinary; Felodipine belongs to Cardiovascular.
Why it happens
Additive vasodilation from alpha-1 blockade and dihydropyridine calcium channel blockade.
What to do
Monitor blood pressure and orthostatic symptoms during initiation and titration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxazosin
- Alfuzosin + Doxazosin Major
- Amifostine + Doxazosin Major
- Avanafil + Doxazosin Major
- Doxazosin + Dutasteride-tamsulosin Major
- Doxazosin + Phentolamine Major
- Doxazosin + Prazosin Major
Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Frequently asked questions
Can I take Doxazosin with Felodipine?
MediHelp rates the interaction as moderate. Doxazosin and Felodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The combination can produce additive hypotension, dizziness and peripheral edema, especially at initiation or dose increases. It is a recognized regimen, but needs monitoring.
How serious is the interaction between Doxazosin and Felodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms during initiation and titration.
What other medicines interact with Doxazosin?
MediHelp also lists interactions of Doxazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Doxazosin page.
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