Drug interactions
Doxazosin + Indomethacin
Severity: Moderate
Doxazosin and Indomethacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indomethacin has a notable tendency to raise blood pressure and can antagonize the effect of antihypertensives such as doxazosin. Reduced blood pressure control may occur.
What this interaction means in plain words
Doxazosin and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxazosin belongs to Genitourinary; Indomethacin belongs to Musculoskeletal.
Why it happens
Prostaglandin synthesis inhibition causes sodium and water retention and vasoconstriction.
What to do
Monitor blood pressure during concurrent use and adjust doxazosin; consider an alternative analgesic if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxazosin
- Alfuzosin + Doxazosin Major
- Amifostine + Doxazosin Major
- Avanafil + Doxazosin Major
- Doxazosin + Dutasteride-tamsulosin Major
- Doxazosin + Phentolamine Major
- Doxazosin + Prazosin Major
Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Frequently asked questions
Can I take Doxazosin with Indomethacin?
MediHelp rates the interaction as moderate. Doxazosin and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indomethacin has a notable tendency to raise blood pressure and can antagonize the effect of antihypertensives such as doxazosin. Reduced blood pressure control may occur.
How serious is the interaction between Doxazosin and Indomethacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during concurrent use and adjust doxazosin; consider an alternative analgesic if control worsens.
What other medicines interact with Doxazosin?
MediHelp also lists interactions of Doxazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Doxazosin page.
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