Drug interactions
Doxazosin + Levodopa
Severity: Moderate
Doxazosin and Levodopa: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levodopa can cause orthostatic hypotension, particularly at initiation and dose increases. Combined with doxazosin, additive postural hypotension may cause dizziness, falls or syncope.
What this interaction means in plain words
Doxazosin and Levodopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxazosin belongs to Genitourinary; Levodopa belongs to Central Nervous System.
Why it happens
Additive hypotension from alpha-1 blockade and levodopa-derived dopaminergic vasodilation and autonomic effects.
What to do
Measure supine and standing blood pressure when starting or adjusting levodopa. Lower the doxazosin dose if orthostatic symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxazosin
- Alfuzosin + Doxazosin Major
- Amifostine + Doxazosin Major
- Avanafil + Doxazosin Major
- Doxazosin + Dutasteride-tamsulosin Major
- Doxazosin + Phentolamine Major
- Doxazosin + Prazosin Major
Other interactions of Levodopa
- Isocarboxazid + Levodopa Contraindicated
- Levodopa + Phenelzine Contraindicated
- Levodopa + Phenelzine (nonselective MAOI) Contraindicated
- Levodopa + Procarbazine Contraindicated
- Levodopa + Tranylcypromine Contraindicated
- Amisulpride + Levodopa Major
Frequently asked questions
Can I take Doxazosin with Levodopa?
MediHelp rates the interaction as moderate. Doxazosin and Levodopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levodopa can cause orthostatic hypotension, particularly at initiation and dose increases. Combined with doxazosin, additive postural hypotension may cause dizziness, falls or syncope.
How serious is the interaction between Doxazosin and Levodopa?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure supine and standing blood pressure when starting or adjusting levodopa. Lower the doxazosin dose if orthostatic symptoms develop.
What other medicines interact with Doxazosin?
MediHelp also lists interactions of Doxazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Doxazosin page.
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