Drug interactions
Doxazosin + Nadolol
Severity: Moderate
Doxazosin and Nadolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Together these drugs lower blood pressure more than either alone, and the first-dose hypotensive response to doxazosin may be exaggerated. Patients may experience dizziness or fainting on standing.
What this interaction means in plain words
Doxazosin and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxazosin belongs to Genitourinary; Nadolol belongs to Cardiovascular.
Why it happens
Additive hypotension from alpha-1 adrenergic blockade and nonselective beta blockade.
What to do
Titrate doxazosin slowly from a low dose and monitor orthostatic blood pressure. Advise patients to rise slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Doxazosin and Nadolol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Doxazosin
- Alfuzosin + Doxazosin Major
- Amifostine + Doxazosin Major
- Avanafil + Doxazosin Major
- Doxazosin + Dutasteride-tamsulosin Major
- Doxazosin + Phentolamine Major
- Doxazosin + Prazosin Major
Other interactions of Nadolol
Frequently asked questions
Can I take Doxazosin with Nadolol?
MediHelp rates the interaction as moderate. Doxazosin and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Together these drugs lower blood pressure more than either alone, and the first-dose hypotensive response to doxazosin may be exaggerated. Patients may experience dizziness or fainting on standing.
How serious is the interaction between Doxazosin and Nadolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate doxazosin slowly from a low dose and monitor orthostatic blood pressure. Advise patients to rise slowly.
What other medicines interact with Doxazosin?
MediHelp also lists interactions of Doxazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Doxazosin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
