Drug interactions
Doxazosin + Nebivolol
Severity: Moderate
Doxazosin and Nebivolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining doxazosin with nebivolol produces additive blood pressure lowering. Nebivolol also has vasodilating properties, which may add to postural hypotension.
What this interaction means in plain words
Doxazosin and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxazosin belongs to Genitourinary; Nebivolol belongs to Cardiovascular.
Why it happens
Additive hypotensive effects of alpha-1 blockade and beta-1 blockade with nitric oxide-mediated vasodilation.
What to do
Start with low doses and titrate gradually while monitoring orthostatic blood pressure. Counsel the patient about dizziness on standing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxazosin
- Alfuzosin + Doxazosin Major
- Amifostine + Doxazosin Major
- Avanafil + Doxazosin Major
- Doxazosin + Dutasteride-tamsulosin Major
- Doxazosin + Phentolamine Major
- Doxazosin + Prazosin Major
Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Frequently asked questions
Can I take Doxazosin with Nebivolol?
MediHelp rates the interaction as moderate. Doxazosin and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining doxazosin with nebivolol produces additive blood pressure lowering. Nebivolol also has vasodilating properties, which may add to postural hypotension.
How serious is the interaction between Doxazosin and Nebivolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses and titrate gradually while monitoring orthostatic blood pressure. Counsel the patient about dizziness on standing.
What other medicines interact with Doxazosin?
MediHelp also lists interactions of Doxazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Doxazosin page.
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