Drug interactions
Doxazosin + Nicardipine
Severity: Moderate
Doxazosin and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxazosin and nicardipine both lower blood pressure through vasodilation, so combined use gives additive effects. Dizziness, orthostatic hypotension and reflex tachycardia can occur, especially at initiation.
What this interaction means in plain words
Doxazosin and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxazosin belongs to Genitourinary; Nicardipine belongs to Cardiovascular.
Why it happens
Additive vasodilation via alpha-1 adrenergic blockade and calcium channel blockade.
What to do
Start the added drug at a low dose and titrate gradually while monitoring blood pressure and orthostatic symptoms. Reduce doses if symptomatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxazosin
- Alfuzosin + Doxazosin Major
- Amifostine + Doxazosin Major
- Avanafil + Doxazosin Major
- Doxazosin + Dutasteride-tamsulosin Major
- Doxazosin + Phentolamine Major
- Doxazosin + Prazosin Major
Other interactions of Nicardipine
Frequently asked questions
Can I take Doxazosin with Nicardipine?
MediHelp rates the interaction as moderate. Doxazosin and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxazosin and nicardipine both lower blood pressure through vasodilation, so combined use gives additive effects. Dizziness, orthostatic hypotension and reflex tachycardia can occur, especially at initiation.
How serious is the interaction between Doxazosin and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start the added drug at a low dose and titrate gradually while monitoring blood pressure and orthostatic symptoms. Reduce doses if symptomatic hypotension develops.
What other medicines interact with Doxazosin?
MediHelp also lists interactions of Doxazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Doxazosin page.
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