Drug interactions
Doxazosin + Treprostinil
Severity: Moderate
Doxazosin and Treprostinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Treprostinil is a potent vasodilator and can add to the blood pressure lowering of doxazosin. This may cause symptomatic hypotension, dizziness or syncope.
What this interaction means in plain words
Doxazosin and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxazosin belongs to Genitourinary; Treprostinil belongs to Cardiovascular.
Why it happens
Additive vasodilation through prostacyclin-receptor agonism and alpha-1 blockade.
What to do
Monitor blood pressure and symptoms of hypotension when starting or titrating either drug. Reduce the antihypertensive dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxazosin
- Alfuzosin + Doxazosin Major
- Amifostine + Doxazosin Major
- Avanafil + Doxazosin Major
- Doxazosin + Dutasteride-tamsulosin Major
- Doxazosin + Phentolamine Major
- Doxazosin + Prazosin Major
Other interactions of Treprostinil
Frequently asked questions
Can I take Doxazosin with Treprostinil?
MediHelp rates the interaction as moderate. Doxazosin and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Treprostinil is a potent vasodilator and can add to the blood pressure lowering of doxazosin. This may cause symptomatic hypotension, dizziness or syncope.
How serious is the interaction between Doxazosin and Treprostinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and symptoms of hypotension when starting or titrating either drug. Reduce the antihypertensive dose if hypotension occurs.
What other medicines interact with Doxazosin?
MediHelp also lists interactions of Doxazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Doxazosin page.
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