Drug interactions
Doxepin + Gabapentin
Severity: Moderate
Doxepin and Gabapentin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin is sedating, especially at hypnotic doses, and gabapentin also causes drowsiness. Together they can increase sedation and impair coordination and alertness.
What this interaction means in plain words
Doxepin and Gabapentin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxepin belongs to Dermatology; Gabapentin belongs to Central Nervous System.
Why it happens
Additive central nervous system depression.
What to do
Use the lowest effective doses and monitor for sedation, especially in older adults. Counsel on driving and falls risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gabapentin
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Gabapentin?
MediHelp rates the interaction as moderate. Doxepin and Gabapentin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxepin is sedating, especially at hypnotic doses, and gabapentin also causes drowsiness. Together they can increase sedation and impair coordination and alertness.
How serious is the interaction between Doxepin and Gabapentin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation, especially in older adults. Counsel on driving and falls risk.
What other medicines interact with Gabapentin?
MediHelp also lists interactions of Gabapentin with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Gabapentin page.
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