Drug interactions
Doxepin + Glibenclamide
Severity: Minor
Doxepin and Glibenclamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants such as doxepin have occasionally been associated with hypoglycemia or altered glucose control in patients taking antidiabetic drugs. Tricyclics can also blunt or mask some adrenergic warning symptoms of low blood sugar. The effect is inconsistent and usually modest.
What this interaction means in plain words
Doxepin and Glibenclamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doxepin belongs to Dermatology; Glibenclamide belongs to Endocrine.
Why it happens
Possible additive glucose lowering through altered insulin sensitivity or secretion; the mechanism is not firmly established.
What to do
Check blood glucose more often when doxepin is started or stopped in a patient on glyburide. Counsel the patient about hypoglycemia symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Glibenclamide?
MediHelp rates the interaction as minor. Doxepin and Glibenclamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants such as doxepin have occasionally been associated with hypoglycemia or altered glucose control in patients taking antidiabetic drugs. Tricyclics can also blunt or mask some adrenergic warning symptoms of low blood sugar. The effect is inconsistent and usually modest.
How serious is the interaction between Doxepin and Glibenclamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood glucose more often when doxepin is started or stopped in a patient on glyburide. Counsel the patient about hypoglycemia symptoms.
What other medicines interact with Glibenclamide?
MediHelp also lists interactions of Glibenclamide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glibenclamide page.
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