Drug interactions
Doxepin + Insulin aspart
Severity: Minor
Doxepin and Insulin aspart: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants such as doxepin have occasionally been associated with altered glycemic control and may modestly enhance the glucose-lowering effect of insulin. The effect is inconsistent and usually small, but hypoglycemia could be more frequent in some patients.
What this interaction means in plain words
Doxepin and Insulin aspart have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doxepin belongs to Dermatology; Insulin aspart belongs to Endocrine.
Why it happens
Possible additive glucose-lowering effect through altered insulin sensitivity and glucose handling; the mechanism is not firmly established.
What to do
Check blood glucose more often when doxepin is started or stopped in an insulin-treated patient, and reduce the insulin dose if readings fall.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin aspart
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Insulin aspart?
MediHelp rates the interaction as minor. Doxepin and Insulin aspart have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants such as doxepin have occasionally been associated with altered glycemic control and may modestly enhance the glucose-lowering effect of insulin. The effect is inconsistent and usually small, but hypoglycemia could be more frequent in some patients.
How serious is the interaction between Doxepin and Insulin aspart?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood glucose more often when doxepin is started or stopped in an insulin-treated patient, and reduce the insulin dose if readings fall.
What other medicines interact with Insulin aspart?
MediHelp also lists interactions of Insulin aspart with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin aspart page.
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