Drug interactions
Doxepin + Insulin lispro
Severity: Minor
Doxepin and Insulin lispro: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants such as doxepin have been associated with altered glucose control and occasionally enhanced hypoglycemia in diabetic patients on insulin. Tricyclics may also mask some hypoglycemia symptoms through anticholinergic effects.
What this interaction means in plain words
Doxepin and Insulin lispro have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doxepin belongs to Dermatology; Insulin lispro belongs to Endocrine.
Why it happens
Possible effects on insulin sensitivity and glucose metabolism; mechanism not fully established.
What to do
Monitor blood glucose when starting or stopping doxepin and adjust insulin lispro as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin lispro
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Insulin lispro?
MediHelp rates the interaction as minor. Doxepin and Insulin lispro have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants such as doxepin have been associated with altered glucose control and occasionally enhanced hypoglycemia in diabetic patients on insulin. Tricyclics may also mask some hypoglycemia symptoms through anticholinergic effects.
How serious is the interaction between Doxepin and Insulin lispro?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping doxepin and adjust insulin lispro as needed.
What other medicines interact with Insulin lispro?
MediHelp also lists interactions of Insulin lispro with, for example, Alogliptin-pioglitazone, Ethanol, Metreleptin. The full list is on the Insulin lispro page.
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