Drug interactions
Doxepin + Octreotide
Severity: Moderate
Doxepin and Octreotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin can prolong the QT interval at higher doses, and octreotide may add to this through bradycardia and conduction effects. The risk is mainly relevant in patients with other cardiac or electrolyte risk factors.
What this interaction means in plain words
Doxepin and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxepin belongs to Dermatology; Octreotide belongs to Endocrine.
Why it happens
Additive QTc prolongation.
What to do
Obtain a baseline ECG in at-risk patients, use the lowest effective doxepin dose, and monitor QTc and heart rate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Octreotide
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Octreotide?
MediHelp rates the interaction as moderate. Doxepin and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxepin can prolong the QT interval at higher doses, and octreotide may add to this through bradycardia and conduction effects. The risk is mainly relevant in patients with other cardiac or electrolyte risk factors.
How serious is the interaction between Doxepin and Octreotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG in at-risk patients, use the lowest effective doxepin dose, and monitor QTc and heart rate.
What other medicines interact with Octreotide?
MediHelp also lists interactions of Octreotide with, for example, Adagrasib, Amisulpride, Arsenic trioxide. The full list is on the Octreotide page.
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