Drug interactions
Doxepin + Pirbuterol
Severity: Moderate
Doxepin and Pirbuterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants such as doxepin can potentiate cardiovascular effects of beta-agonists, including tachycardia and arrhythmia. Pirbuterol labeling advises caution with tricyclics.
What this interaction means in plain words
Doxepin and Pirbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive adrenergic and cardiac effects; tricyclics block norepinephrine reuptake and may enhance vascular responses to beta-agonists.
What to do
Monitor heart rate, blood pressure and ECG during co-therapy. Use the lowest effective pirbuterol dose and consider alternatives in patients with cardiac disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Pirbuterol?
MediHelp rates the interaction as moderate. Doxepin and Pirbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants such as doxepin can potentiate cardiovascular effects of beta-agonists, including tachycardia and arrhythmia. Pirbuterol labeling advises caution with tricyclics.
How serious is the interaction between Doxepin and Pirbuterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG during co-therapy. Use the lowest effective pirbuterol dose and consider alternatives in patients with cardiac disease.
What other medicines interact with Doxepin?
MediHelp also lists interactions of Doxepin with, for example, Isocarboxazid, Phenelzine, Procarbazine. The full list is on the Doxepin page.
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