Drug interactions
Doxepin + Terbutaline
Severity: Moderate
Doxepin and Terbutaline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin may enhance the cardiovascular effects of terbutaline such as tachycardia and arrhythmia, particularly with systemic terbutaline.
What this interaction means in plain words
Doxepin and Terbutaline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxepin belongs to Dermatology; Terbutaline belongs to Respiratory.
Why it happens
Additive adrenergic stimulation with tricyclic norepinephrine reuptake inhibition.
What to do
Monitor heart rate and blood pressure, and watch for palpitations or arrhythmia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Terbutaline
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Terbutaline?
MediHelp rates the interaction as moderate. Doxepin and Terbutaline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxepin may enhance the cardiovascular effects of terbutaline such as tachycardia and arrhythmia, particularly with systemic terbutaline.
How serious is the interaction between Doxepin and Terbutaline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure, and watch for palpitations or arrhythmia.
What other medicines interact with Terbutaline?
MediHelp also lists interactions of Terbutaline with, for example, Carvedilol, Droperidol, Fexinidazole. The full list is on the Terbutaline page.
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