Drug interactions
Doxepin + Topiramate
Severity: Moderate
Doxepin and Topiramate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin is a sedating tricyclic antidepressant, and topiramate adds central depressant and cognitive effects. The combination can cause pronounced drowsiness and impaired concentration.
What this interaction means in plain words
Doxepin and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxepin belongs to Dermatology; Topiramate belongs to Central Nervous System.
Why it happens
Additive CNS depression from H1 antagonism and anticholinergic effects of doxepin plus topiramate.
What to do
Monitor for oversedation and cognitive slowing, and start with low doses. Counsel patients to avoid driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Topiramate
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Topiramate?
MediHelp rates the interaction as moderate. Doxepin and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxepin is a sedating tricyclic antidepressant, and topiramate adds central depressant and cognitive effects. The combination can cause pronounced drowsiness and impaired concentration.
How serious is the interaction between Doxepin and Topiramate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and cognitive slowing, and start with low doses. Counsel patients to avoid driving until the response is known.
What other medicines interact with Topiramate?
MediHelp also lists interactions of Topiramate with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Topiramate page.
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