Drug interactions
Doxepin + Triprolidine
Severity: Moderate
Doxepin and Triprolidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin is a tricyclic antidepressant with strong antihistaminic and anticholinergic properties and marked sedative effects. Combined with triprolidine it may cause pronounced drowsiness, confusion, dry mouth, urinary retention and constipation, particularly in older adults.
What this interaction means in plain words
Doxepin and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxepin belongs to Dermatology; Triprolidine belongs to Respiratory.
Why it happens
Additive H1-antihistaminic, antimuscarinic and CNS depressant effects.
What to do
Monitor for oversedation and anticholinergic toxicity, and consider a non-sedating antihistamine as an alternative. Reduce doses in elderly patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Doxepin and Triprolidine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Triprolidine
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Triprolidine?
MediHelp rates the interaction as moderate. Doxepin and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxepin is a tricyclic antidepressant with strong antihistaminic and anticholinergic properties and marked sedative effects. Combined with triprolidine it may cause pronounced drowsiness, confusion, dry mouth, urinary retention and constipation, particularly in older adults.
How serious is the interaction between Doxepin and Triprolidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and anticholinergic toxicity, and consider a non-sedating antihistamine as an alternative. Reduce doses in elderly patients.
What other medicines interact with Triprolidine?
MediHelp also lists interactions of Triprolidine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Triprolidine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
