Drug interactions
Doxorubicin + Fostemsavir
Severity: Minor
Doxorubicin and Fostemsavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostemsavir's active metabolite temsavir inhibits BCRP and may raise exposure to BCRP substrates. Doxorubicin levels and toxicity could increase.
What this interaction means in plain words
Doxorubicin and Fostemsavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doxorubicin belongs to Oncology; Fostemsavir belongs to Anti Virals.
Why it happens
Temsavir inhibits BCRP efflux transport, potentially reducing doxorubicin elimination.
What to do
Monitor blood counts and cardiac function. Reduce the doxorubicin dose if toxicity occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Doxorubicin
Other interactions of Fostemsavir
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Doxorubicin with Fostemsavir?
MediHelp rates the interaction as minor. Doxorubicin and Fostemsavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fostemsavir's active metabolite temsavir inhibits BCRP and may raise exposure to BCRP substrates. Doxorubicin levels and toxicity could increase.
How serious is the interaction between Doxorubicin and Fostemsavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac function. Reduce the doxorubicin dose if toxicity occurs.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
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