Drug interactions
Doxorubicin + Isavuconazonium
Severity: Moderate
Doxorubicin and Isavuconazonium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole is a moderate CYP3A4 inhibitor and P-gp inhibitor, so it may raise doxorubicin exposure and toxicity. The legacy direction of effect is reversed; doxorubicin does not meaningfully affect isavuconazole.
What this interaction means in plain words
Doxorubicin and Isavuconazonium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxorubicin belongs to Oncology; Isavuconazonium belongs to Anti Fungals.
Why it happens
Isavuconazole inhibits CYP3A4 and P-gp, decreasing doxorubicin clearance.
What to do
Monitor for myelosuppression, mucositis and cardiotoxicity, and reduce the doxorubicin dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxorubicin
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Doxorubicin with Isavuconazonium?
MediHelp rates the interaction as moderate. Doxorubicin and Isavuconazonium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isavuconazole is a moderate CYP3A4 inhibitor and P-gp inhibitor, so it may raise doxorubicin exposure and toxicity. The legacy direction of effect is reversed; doxorubicin does not meaningfully affect isavuconazole.
How serious is the interaction between Doxorubicin and Isavuconazonium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for myelosuppression, mucositis and cardiotoxicity, and reduce the doxorubicin dose if toxicity occurs.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
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