Drug interactions
Doxorubicin + Lapatinib
Severity: Moderate
Doxorubicin and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib inhibits P-glycoprotein and BCRP and may increase doxorubicin exposure. Both drugs can also reduce left ventricular function, so cardiac risk may be additive. Combined use calls for attention to cardiotoxicity and myelosuppression.
What this interaction means in plain words
Doxorubicin and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxorubicin belongs to Oncology; Lapatinib belongs to Oncology.
Why it happens
Lapatinib inhibits P-glycoprotein efflux of doxorubicin, with additive cardiotoxic effects.
What to do
Assess left ventricular ejection fraction at baseline and periodically, and monitor blood counts. Reduce the doxorubicin dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Doxorubicin and Lapatinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Doxorubicin
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Doxorubicin with Lapatinib?
MediHelp rates the interaction as moderate. Doxorubicin and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib inhibits P-glycoprotein and BCRP and may increase doxorubicin exposure. Both drugs can also reduce left ventricular function, so cardiac risk may be additive. Combined use calls for attention to cardiotoxicity and myelosuppression.
How serious is the interaction between Doxorubicin and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess left ventricular ejection fraction at baseline and periodically, and monitor blood counts. Reduce the doxorubicin dose if toxicity develops.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
