Drug interactions
Doxorubicin + Lenacapavir
Severity: Moderate
Doxorubicin and Lenacapavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir moderately inhibits CYP3A and may increase doxorubicin exposure, with an effect persisting for months after the last subcutaneous dose. This could increase myelosuppression and cardiotoxicity.
What this interaction means in plain words
Doxorubicin and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxorubicin belongs to Oncology; Lenacapavir belongs to Anti Virals.
Why it happens
Lenacapavir inhibits CYP3A4 and P-gp, reducing doxorubicin clearance.
What to do
Monitor blood counts and cardiac function, and reduce the doxorubicin dose if toxicity develops; consult HIV and oncology specialists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxorubicin
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Doxorubicin with Lenacapavir?
MediHelp rates the interaction as moderate. Doxorubicin and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir moderately inhibits CYP3A and may increase doxorubicin exposure, with an effect persisting for months after the last subcutaneous dose. This could increase myelosuppression and cardiotoxicity.
How serious is the interaction between Doxorubicin and Lenacapavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac function, and reduce the doxorubicin dose if toxicity develops; consult HIV and oncology specialists.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
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