Drug interactions
Doxorubicin + Leniolisib
Severity: Moderate
Doxorubicin and Leniolisib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib inhibits BCRP and may increase systemic exposure to doxorubicin. The size of the effect is uncertain, but higher doxorubicin levels could worsen myelosuppression.
What this interaction means in plain words
Doxorubicin and Leniolisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxorubicin belongs to Oncology; Leniolisib belongs to Miscellaneous.
Why it happens
Leniolisib inhibits BCRP-mediated efflux of doxorubicin.
What to do
Monitor blood counts and signs of doxorubicin toxicity. Reduce the doxorubicin dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxorubicin
Other interactions of Leniolisib
Frequently asked questions
Can I take Doxorubicin with Leniolisib?
MediHelp rates the interaction as moderate. Doxorubicin and Leniolisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leniolisib inhibits BCRP and may increase systemic exposure to doxorubicin. The size of the effect is uncertain, but higher doxorubicin levels could worsen myelosuppression.
How serious is the interaction between Doxorubicin and Leniolisib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and signs of doxorubicin toxicity. Reduce the doxorubicin dose if toxicity develops.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
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