Drug interactions
Doxorubicin + Mitotane
Severity: Moderate
Doxorubicin and Mitotane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitotane is a strong CYP3A4 inducer and may lower doxorubicin exposure, potentially reducing efficacy. The effect can persist for weeks after mitotane is stopped because of its long half-life.
What this interaction means in plain words
Doxorubicin and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxorubicin belongs to Oncology; Mitotane belongs to Oncology.
Why it happens
Mitotane induces CYP3A4 (and possibly transporters), increasing doxorubicin clearance.
What to do
Monitor tumor response and toxicity; doxorubicin is used with mitotane in adrenocortical carcinoma regimens, so follow established protocols.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxorubicin
Other interactions of Mitotane
- Doravirine + Mitotane Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Lorlatinib + Mitotane Contraindicated
- Abiraterone + Mitotane Major
- Apixaban + Mitotane Major
- Aprepitant + Mitotane Major
Frequently asked questions
Can I take Doxorubicin with Mitotane?
MediHelp rates the interaction as moderate. Doxorubicin and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mitotane is a strong CYP3A4 inducer and may lower doxorubicin exposure, potentially reducing efficacy. The effect can persist for weeks after mitotane is stopped because of its long half-life.
How serious is the interaction between Doxorubicin and Mitotane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tumor response and toxicity; doxorubicin is used with mitotane in adrenocortical carcinoma regimens, so follow established protocols.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
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