Drug interactions
Doxorubicin + Regorafenib
Severity: Moderate
Doxorubicin and Regorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regorafenib may inhibit BCRP efflux and could raise systemic exposure to doxorubicin. This may increase myelosuppression and cardiotoxicity, though clinical evidence is limited.
What this interaction means in plain words
Doxorubicin and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxorubicin belongs to Oncology; Regorafenib belongs to Oncology.
Why it happens
Possible inhibition of BCRP (ABCG2) transport by regorafenib, reducing doxorubicin efflux.
What to do
Monitor blood counts and cardiac function, tracking cumulative anthracycline dose. Reduce doxorubicin dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxorubicin
Other interactions of Regorafenib
Frequently asked questions
Can I take Doxorubicin with Regorafenib?
MediHelp rates the interaction as moderate. Doxorubicin and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Regorafenib may inhibit BCRP efflux and could raise systemic exposure to doxorubicin. This may increase myelosuppression and cardiotoxicity, though clinical evidence is limited.
How serious is the interaction between Doxorubicin and Regorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac function, tracking cumulative anthracycline dose. Reduce doxorubicin dose if toxicity occurs.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
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