Drug interactions
Doxorubicin + Rifapentine
Severity: Minor
Doxorubicin and Rifapentine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifapentine induces CYP3A4 and P-glycoprotein and may lower doxorubicin exposure. Reduced anticancer effect is possible, although the clinical impact is uncertain.
What this interaction means in plain words
Doxorubicin and Rifapentine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doxorubicin belongs to Oncology; Rifapentine belongs to Anti Bacterial.
Why it happens
Rifapentine induces CYP3A4 and P-gp, possibly increasing doxorubicin elimination.
What to do
Monitor for reduced response to doxorubicin and consider an alternative to rifapentine where feasible.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Doxorubicin
Other interactions of Rifapentine
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Lorlatinib + Rifapentine Contraindicated
- Lurasidone + Rifapentine Contraindicated
- Ranolazine + Rifapentine Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Doxorubicin with Rifapentine?
MediHelp rates the interaction as minor. Doxorubicin and Rifapentine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rifapentine induces CYP3A4 and P-glycoprotein and may lower doxorubicin exposure. Reduced anticancer effect is possible, although the clinical impact is uncertain.
How serious is the interaction between Doxorubicin and Rifapentine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced response to doxorubicin and consider an alternative to rifapentine where feasible.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
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