Drug interactions
Doxorubicin + Ritonavir
Severity: Moderate
Doxorubicin and Ritonavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir inhibits CYP3A4 and P-glycoprotein and may raise doxorubicin concentrations. This can increase myelosuppression, mucositis and cardiotoxicity. Clinical data are limited, but the mechanism is well understood.
What this interaction means in plain words
Doxorubicin and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxorubicin belongs to Oncology; Ritonavir belongs to Anti Virals.
Why it happens
Ritonavir inhibits CYP3A4 and P-gp, reducing doxorubicin metabolism and efflux.
What to do
Monitor blood counts, mucositis and cardiac function closely, and consider doxorubicin dose reduction. Where feasible, use an antiretroviral regimen without a pharmacokinetic booster.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxorubicin
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Doxorubicin with Ritonavir?
MediHelp rates the interaction as moderate. Doxorubicin and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir inhibits CYP3A4 and P-glycoprotein and may raise doxorubicin concentrations. This can increase myelosuppression, mucositis and cardiotoxicity. Clinical data are limited, but the mechanism is well understood.
How serious is the interaction between Doxorubicin and Ritonavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, mucositis and cardiac function closely, and consider doxorubicin dose reduction. Where feasible, use an antiretroviral regimen without a pharmacokinetic booster.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
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