Drug interactions
Doxorubicin + Sarecycline
Severity: Minor
Doxorubicin and Sarecycline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sarecycline is a P-glycoprotein inhibitor in vitro and may increase exposure to P-gp substrates such as doxorubicin. The clinical relevance is uncertain given the low systemic exposure to sarecycline at acne doses. Increased doxorubicin toxicity is theoretically possible.
What this interaction means in plain words
Doxorubicin and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doxorubicin belongs to Oncology; Sarecycline belongs to Anti Bacterial.
Why it happens
Sarecycline may inhibit P-gp, reducing doxorubicin efflux.
What to do
No routine adjustment is required; monitor for increased doxorubicin toxicity such as myelosuppression.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Doxorubicin
Other interactions of Sarecycline
- Acitretin + Sarecycline Contraindicated
- Isotretinoin + Sarecycline Major
- Sarecycline + Tretinoin Major
- Aluminum hydroxide + Sarecycline Moderate
- Calcium carbonate + Sarecycline Moderate
- Calcium + Sarecycline Moderate
Frequently asked questions
Can I take Doxorubicin with Sarecycline?
MediHelp rates the interaction as minor. Doxorubicin and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sarecycline is a P-glycoprotein inhibitor in vitro and may increase exposure to P-gp substrates such as doxorubicin. The clinical relevance is uncertain given the low systemic exposure to sarecycline at acne doses. Increased doxorubicin toxicity is theoretically possible.
How serious is the interaction between Doxorubicin and Sarecycline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is required; monitor for increased doxorubicin toxicity such as myelosuppression.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
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