Drug interactions
Doxorubicin + Terbinafine
Severity: Minor
Doxorubicin and Terbinafine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxorubicin is a minor CYP2D6 substrate and is mainly handled by carbonyl reductases, P-glycoprotein and CYP3A4. A clinically meaningful change in exposure with terbinafine is not expected.
What this interaction means in plain words
Doxorubicin and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doxorubicin belongs to Oncology; Terbinafine belongs to Anti Fungals.
Why it happens
Possible minor reduction in CYP2D6-mediated doxorubicin metabolism; not established as clinically relevant.
What to do
No adjustment is needed; monitor for doxorubicin toxicity as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Doxorubicin and Terbinafine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Terbinafine
- Terbinafine + Thioridazine Contraindicated
- Desipramine + Terbinafine Major
- Eliglustat + Terbinafine Major
- Flecainide + Terbinafine Major
- Imipramine + Terbinafine Major
- Maprotiline + Terbinafine Major
Other interactions of Doxorubicin
Frequently asked questions
Can I take Doxorubicin with Terbinafine?
MediHelp rates the interaction as minor. Doxorubicin and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Doxorubicin is a minor CYP2D6 substrate and is mainly handled by carbonyl reductases, P-glycoprotein and CYP3A4. A clinically meaningful change in exposure with terbinafine is not expected.
How serious is the interaction between Doxorubicin and Terbinafine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is needed; monitor for doxorubicin toxicity as usual.
What other medicines interact with Terbinafine?
MediHelp also lists interactions of Terbinafine with, for example, Thioridazine, Desipramine, Eliglustat. The full list is on the Terbinafine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
