Drug interactions
Doxorubicin + Voxelotor
Severity: Minor
Doxorubicin and Voxelotor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor inhibits CYP3A4 and could modestly raise doxorubicin levels, but CYP3A4 is only a minor route for doxorubicin. The clinical significance is uncertain and the effect is predicted rather than documented.
What this interaction means in plain words
Doxorubicin and Voxelotor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doxorubicin belongs to Oncology; Voxelotor belongs to Miscellaneous.
Why it happens
Voxelotor weakly inhibits CYP3A4, potentially reducing doxorubicin metabolism.
What to do
No routine dose change is needed; monitor for doxorubicin toxicity such as myelosuppression and mucositis.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Doxorubicin
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Doxorubicin with Voxelotor?
MediHelp rates the interaction as minor. Doxorubicin and Voxelotor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Voxelotor inhibits CYP3A4 and could modestly raise doxorubicin levels, but CYP3A4 is only a minor route for doxorubicin. The clinical significance is uncertain and the effect is predicted rather than documented.
How serious is the interaction between Doxorubicin and Voxelotor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for doxorubicin toxicity such as myelosuppression and mucositis.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
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