Drug interactions
Doxorubicin liposomal + Mifepristone
Severity: Moderate
Doxorubicin liposomal and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone may inhibit CYP3A4 and P-glycoprotein and could increase doxorubicin exposure. This may heighten myelosuppression and cardiotoxicity, though liposomal formulation lowers free drug exposure.
What this interaction means in plain words
Doxorubicin liposomal and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible CYP3A4 and P-glycoprotein inhibition reduces doxorubicin clearance.
What to do
Monitor blood counts and cardiac function. Reduce the dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Doxorubicin liposomal and Mifepristone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Doxorubicin liposomal with Mifepristone?
MediHelp rates the interaction as moderate. Doxorubicin liposomal and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone may inhibit CYP3A4 and P-glycoprotein and could increase doxorubicin exposure. This may heighten myelosuppression and cardiotoxicity, though liposomal formulation lowers free drug exposure.
How serious is the interaction between Doxorubicin liposomal and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac function. Reduce the dose if toxicity develops.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
