Drug interactions
Doxorubicin liposomal + Paclitaxel
Severity: Moderate
Doxorubicin liposomal and Paclitaxel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paclitaxel can alter doxorubicin disposition and has been associated with higher doxorubicin exposure, increasing the risk of cardiotoxicity and myelosuppression. The effect is reported mainly with conventional doxorubicin and is less certain for liposomal formulations.
What this interaction means in plain words
Doxorubicin liposomal and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Paclitaxel (and its vehicle) may reduce doxorubicin biliary and renal elimination, likely via efflux transporter effects.
What to do
Monitor cardiac function and blood counts, and track cumulative anthracycline dose. Consider sequencing doxorubicin before paclitaxel.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paclitaxel
Frequently asked questions
Can I take Doxorubicin liposomal with Paclitaxel?
MediHelp rates the interaction as moderate. Doxorubicin liposomal and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paclitaxel can alter doxorubicin disposition and has been associated with higher doxorubicin exposure, increasing the risk of cardiotoxicity and myelosuppression. The effect is reported mainly with conventional doxorubicin and is less certain for liposomal formulations.
How serious is the interaction between Doxorubicin liposomal and Paclitaxel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cardiac function and blood counts, and track cumulative anthracycline dose. Consider sequencing doxorubicin before paclitaxel.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporin. The full list is on the Paclitaxel page.
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