Drug interactions
Doxorubicin liposomal + Quinidine
Severity: Moderate
Doxorubicin liposomal and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine inhibits P-gp, which can raise doxorubicin exposure from conventional formulations. For the liposomal form, drug disposition differs and the clinical impact is uncertain, but increased toxicity such as myelosuppression and cardiotoxicity is theoretically possible.
What this interaction means in plain words
Doxorubicin liposomal and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Quinidine inhibits P-gp-mediated efflux of doxorubicin.
What to do
Monitor blood counts and cardiac function, and watch for increased doxorubicin toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Doxorubicin liposomal with Quinidine?
MediHelp rates the interaction as moderate. Doxorubicin liposomal and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine inhibits P-gp, which can raise doxorubicin exposure from conventional formulations. For the liposomal form, drug disposition differs and the clinical impact is uncertain, but increased toxicity such as myelosuppression and cardiotoxicity is theoretically possible.
How serious is the interaction between Doxorubicin liposomal and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac function, and watch for increased doxorubicin toxicity.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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