Drug interactions
Doxorubicin liposomal + Terbinafine
Severity: Minor
Doxorubicin liposomal and Terbinafine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxorubicin is a CYP2D6 substrate, but CYP2D6 is a minor route and liposomal formulation alters its disposition. Clinically significant increases are not well established.
What this interaction means in plain words
Doxorubicin liposomal and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Terbinafine inhibits CYP2D6, which could modestly reduce doxorubicin metabolism.
What to do
No empiric dose change is needed; monitor for increased myelosuppression and cardiotoxicity during therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Terbinafine
- Terbinafine + Thioridazine Contraindicated
- Desipramine + Terbinafine Major
- Eliglustat + Terbinafine Major
- Flecainide + Terbinafine Major
- Imipramine + Terbinafine Major
- Maprotiline + Terbinafine Major
Frequently asked questions
Can I take Doxorubicin liposomal with Terbinafine?
MediHelp rates the interaction as minor. Doxorubicin liposomal and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Doxorubicin is a CYP2D6 substrate, but CYP2D6 is a minor route and liposomal formulation alters its disposition. Clinically significant increases are not well established.
How serious is the interaction between Doxorubicin liposomal and Terbinafine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change is needed; monitor for increased myelosuppression and cardiotoxicity during therapy.
What other medicines interact with Terbinafine?
MediHelp also lists interactions of Terbinafine with, for example, Thioridazine, Desipramine, Eliglustat. The full list is on the Terbinafine page.
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