Drug interactions
Doxorubicin liposomal + Verapamil
Severity: Moderate
Doxorubicin liposomal and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil may increase doxorubicin exposure and intracellular retention, potentially enhancing myelosuppression and cardiotoxicity. Calcium channel blockers have also been linked to heightened anthracycline cardiac risk. The effect with liposomal formulation is less well defined.
What this interaction means in plain words
Doxorubicin liposomal and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Verapamil inhibits P-glycoprotein and CYP3A4, reducing doxorubicin efflux and clearance.
What to do
Monitor left ventricular function and blood counts, and consider an alternative antihypertensive when feasible. Keep cumulative anthracycline dose limits in mind.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Doxorubicin liposomal with Verapamil?
MediHelp rates the interaction as moderate. Doxorubicin liposomal and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil may increase doxorubicin exposure and intracellular retention, potentially enhancing myelosuppression and cardiotoxicity. Calcium channel blockers have also been linked to heightened anthracycline cardiac risk. The effect with liposomal formulation is less well defined.
How serious is the interaction between Doxorubicin liposomal and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor left ventricular function and blood counts, and consider an alternative antihypertensive when feasible. Keep cumulative anthracycline dose limits in mind.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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