Drug interactions
Doxorubicin liposomal + Zidovudine
Severity: Moderate
Doxorubicin liposomal and Zidovudine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs suppress bone marrow, so combining them may worsen neutropenia and anemia. Doxorubicin has also been reported to antagonise the antiviral activity of zidovudine in vitro, possibly reducing its effect.
What this interaction means in plain words
Doxorubicin liposomal and Zidovudine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive myelosuppression plus in vitro antagonism of zidovudine activation, likely by competition in intracellular phosphorylation.
What to do
Avoid the combination where possible, and use an alternative antiretroviral if feasible. If used together, monitor blood counts frequently and HIV viral load.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zidovudine
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Zidovudine Contraindicated
- Stavudine + Zidovudine Contraindicated
- Atidarsagene autotemcel + Zidovudine Major
- Betibeglogene autotemcel + Zidovudine Major
- Carboplatin + Zidovudine Major
- Cisplatin + Zidovudine Major
Frequently asked questions
Can I take Doxorubicin liposomal with Zidovudine?
MediHelp rates the interaction as moderate. Doxorubicin liposomal and Zidovudine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs suppress bone marrow, so combining them may worsen neutropenia and anemia. Doxorubicin has also been reported to antagonise the antiviral activity of zidovudine in vitro, possibly reducing its effect.
How serious is the interaction between Doxorubicin liposomal and Zidovudine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, and use an alternative antiretroviral if feasible. If used together, monitor blood counts frequently and HIV viral load.
What other medicines interact with Zidovudine?
MediHelp also lists interactions of Zidovudine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Stavudine, Atidarsagene autotemcel. The full list is on the Zidovudine page.
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