Drug interactions
Doxycycline + Ferric oxyhydroxide
Severity: Moderate
Doxycycline and Ferric oxyhydroxide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iron-containing binders can bind doxycycline in the gut and reduce its absorption, risking reduced antibacterial effect.
What this interaction means in plain words
Doxycycline and Ferric oxyhydroxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxycycline belongs to Anti Bacterial; Ferric oxyhydroxide belongs to Gastrointestinal Tract.
Why it happens
Chelation of doxycycline by iron and other cations in the gastrointestinal tract.
What to do
Take doxycycline at least 1 hour before ferric oxyhydroxide.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ferric oxyhydroxide
Other interactions of Doxycycline
- Acitretin + Doxycycline Contraindicated
- Aminolevulinic acid + Doxycycline Major
- Cholera vaccine + Doxycycline Major
- Doxycycline + Isotretinoin Major
- Doxycycline + Methoxyflurane Major
- Doxycycline + Microbiota Major
Frequently asked questions
Can I take Doxycycline with Ferric oxyhydroxide?
MediHelp rates the interaction as moderate. Doxycycline and Ferric oxyhydroxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iron-containing binders can bind doxycycline in the gut and reduce its absorption, risking reduced antibacterial effect.
How serious is the interaction between Doxycycline and Ferric oxyhydroxide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take doxycycline at least 1 hour before ferric oxyhydroxide.
What other medicines interact with Ferric oxyhydroxide?
MediHelp also lists interactions of Ferric oxyhydroxide with, for example, Levothyroxine, Acetylsalicylic acid, Cefalexin. The full list is on the Ferric oxyhydroxide page.
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